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HOW IT WORKS & BENEFITS
Reverse your age by activating your own stem cells
phototherapy / photobiomodulation
GHK-Cu tripeptide
stem cell activation
WHAT YOU CAN EXPECT FROM STEM CELL ACTIVATION (X39 summary)
STUDIES & PUBLICATIONS PHOTO-BIOMODULATION PATCHES
Reverse your age by activating your own stem cells
proven stem cell activation by increased GHK-Cu levels with X39
statistically significant increase in 40-80 year old within 2-7 days
X39 - stem cell activation (GHK-Cu pathway)
Double-Blind Testing of the Lifewave X39 Patch to Determine GHK-Cu Production Levels, CA Connor et al., Internal Med Res Open J, Volume 6(1): 1–3, 2021
Abstract
Purpose: To determine if the LifeWave X39 non-transdermal photobiomodulation active patch would show improved production of GHK-Cu over controls in a double blind randomized controlled trial.
Materials: BD Vacutainer Safety Loc Blood Collection sets with Pre-attached holder sized 21GX0.75 or 23GX0.75 and lavender top tubes. Kendro Sorvall Biofuge Centrifuge 75005184+ and AB Sciex API4000 Qtrap. Analysis software included: Qtrap Analyst software 1.6.2 and R software version 3.5.1. Statistical analyses were conducted using R software (version 3.5.1; http://www.r-project.org/).
Method: Sixty people age 40-80 were computer randomized into two groups. One lavender top tube was drawn and then spun in Kendro Sorvall centrifuge for 10 minutes at 1300 rcf. The plasma was placed in cryo tubes and flash frozen to -22C then shipped in dry ice to laboratory for analysis. The filtrate was concentrated by speed-vac and reconstituted with de-ionized water to 50 ul and analyzed with AB Sciex API4000 Qtrap. Statistical assessments were evaluated using a nonparametric Wilcoxon signed rank test, p values are two-sided and p<0.05 was used to define statistical significance.
Results: A significant increase in GHK-Cu concentration in the blood of the active group was seen comparing changes from Day 2 to Day 7 between Group A vs. Group B in GHK-Cu Concentration (ng/ml) at p<0.035 and in Total GHK-Cu (ng) at p<0.03.
Conclusion: This study showed a significant increase in the GHK-Cu concentration present in the blood as a result of wearing the LifeWave X39 patch for 1 week in individuals age 40 to 80. This is seen from Day 2 to Day 7 between Active vs. Control in GHK-Cu Concentration (ng/ml) at p<0.035 and in Total GHK-Cu (ng) at p<0.03.
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Phototherapy Induced Metabolism Change Produced by the LifeWave X39 Non-transdermal Patch, MH Connor et al., Int J of Research Studies in Medical and Health Sciences, Vol 6, Issue 5, 2021, PP 08-14
Abstract
Purpose: To determine X-39 patch impact in stimulation of Copper peptide biosynthesis and bio-available amino acid levels, neurotransmitters production, memory, sleep quality, vitality, muscle relaxation and blood pressure. Materials: Biography Infinity physiology suite: Heart rate variability (HRV), GSR, EMG, EKG, blood volume pulse (BVP), temperature and respiration. Questionnaires: Marlow-Crowne, Global Mood Scale, Pittsburg Sleep Quality Index, Arizona Integrative Outcomes scale. WAIS III memory test. Amino acid and neurotransmitters testing of urine. Method: Subjects were recruited (age 40 – 81), consented, randomized and scheduled. Data taken day 1, day 2, and day 7 except Marlow-Crowne taken day 1 and day 7. Results: Improvements in short term memory p<0.001, sleep quality p<0.04, vitality p<0.03 day 2 and p<0.08 at day 7. Blood pressure change in VLF on day 7 at p<0.02, respiration on day 7 at p<0.04. Increase in amino acids: Creatinine, Normetanephrine, methionine, homocystine, isoleucine, glutamine, cysteine, 5-hydroxytrytophane, β-aminobutyric-acid. Conclusion: The results of the double blind randomized controlled trial of 50 subjects with mean age 63 years, using the LifeWave non-transdermal X-39 phototherapy patch worn 8-12 hours per day for seven days produced an increase in 8 amino acids at significant levels. The study showed, there was an improvement in short term memory as measured by the WAIS III memory test at significant levels over 7 days, in Quality of Sleep at significant levels within 24 hours and a self reported increase in vitality at near significant levels in 7 days as measured by the Arizona Integrative Outcomes scale.
Our findings suggest this patch is not only stimulating the biosynthesis of copper-peptide production, but also increases neurotransmitters production and improves metabolism. Additional studies could address underlying mechanisms of action to the phototherapy process and longer periods of study might be explored for additional potential physical changes and longevity of the demonstrated changes.
X49 - stem cell activation (AHK-Cu pathway)
Bone and Muscle Support in Ageing Women with LifeWave X49 Patch, MH Connor et al., BJSTR.2022.47.007513
Abstract
Purpose: To determine if the Life Wave X49TM patch supports bone and muscle health in women ages 40-80. Results: Significant decreases from baseline were observed for AHK-Cu. The per- centages of subjects with a >30% decrease in creatine levels from baseline (NTx re- sponse) to the post intervention time points were significant. Secondary to NTx, we also saw a significant decrease in Hydroxyproline at the post intervention assessment time points. The combination of these three points in this early data suggests that X49 TM has the potential to decrease the breakdown of bones during the cycle of bone re- pair. In addition, we saw 14 amino acids change production levels at significance over the 60 days. The amino acids which changed were also spread between the chatechol- amine, serotinergic, glutaminergic, transulferation, and histidine pathways, giving a very broad impact. Conclusion: This study explores changes in AHK-Cu peptide production and changes in NTx production to see if the Life Wave X49 TM patch supports improved bone density. There was a significant change in both AHK-Cu and NTx. Study data is sufficiently significant to warrant further research.
X39, X49 and Aeon - osteoarthritis study (GHK-Cu v AHK-Cu pathway activation, in combination with anti-inflammation Aeon patch)
Effect of X39, X49 and Aeon Patches on Individuals with Osteoarthritis: Pilot Research, G Chevalier et al., PSY TEk labs, Research Report, Data on file (2021)
Summary
The VAS pain scale showed that both groups experienced significant pain decrease. The X49 with Aeon patches group experienced the most dramatic decrease in pain at Visit 2 while the X39 and Aeon patches group experienced a significant decrease in pain at Visit 3 only.
The WOMAC showed statistically significant improvements in pain, stiffness, and functional limitations for the X39 with Aeon patches group but no significant improvement for the X49 with Aeon patches group.
The cortisol production due to stress decrease very significantly at Visit 2 for the X39 with Aeon patches group but went back up at Visit 3 while the X49 with Aeon patches group showed significant improvement at Visit 3. This illustrate how different the effects of the X39 and the X49 patches on stress as it relates to cortisol production are.
The X49 with Aeon patches group showed an improvement in oxyhemoglobin percentage for the X49 with Aeon group compared to the X39 with Aeon group at Visit 3.
There were no significant results for hs-CRP, cortisol in relation to inflammation, and bone mineral density. Hs-CRP and cortisol are a marker and a promoter of inflammation, respectively and since the participants had osteoarthritis with pain, it is not surprising to find no significant results since we expect inflammation to have been very high for a long time for these people.
STUDIES & MEDICAL PUBLICATIONS GHK-Cu tripeptide
Independent GHK-Cu Landmark Publications (meta-studies)
no affiliation with X39 manufacturer
peer-reviewed published on PubMed
GHK and DNA: resetting the human genome to health, L Pickart et al., Biomed Res Int.; 2014:151479. Epub 2014 Sep 11.
Abstract
During human aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Recently, GHK has been found to reset genes of diseased cells from patients with cancer or COPD to a more healthy state. Cancer cells reset their programmed cell death system while COPD patients’ cells shut down tissue destructive genes and stimulate repair and remodeling activities. In this paper, we discuss GHK’s effect on genes that suppress fibrinogen synthesis, the insulin/insulin-like system, and cancer growth plus activation of genes that increase the ubiquitin-proteasome system, DNA repair, antioxidant systems, and healing by the TGF beta superfamily. A variety of methods and dosages to effectively use GHK to reset genes to a healthier state are also discussed.
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data, L Pickart et al., Int. J. Mol. Sci. 2018, 19, 1987; doi:10.3390/ijms19071987
Abstract
Abstract: The human peptide GHK (glycyl-L-histidyl-L-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NF B, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.
The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline, L Pickart et al., Brain Sci. 2017, 7, 20; doi:10.3390/brainsci7020020
Abstract
Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-L-histidyl-L-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions. GHK, which declines with age, has health promoting effects on many tissues such as chondrocytes, liver cells and human fibroblasts, improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, boney tissue), increases collagen, decorin, angiogenesis, and nerve outgrowth, possesses anti-oxidant, anti-inflammatory, anti-pain and anti-anxiety effects, increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Studies using the Broad Institute Connectivity Map show that GHK peptide modulates expression of multiple genes, resetting pathological gene expression patterns back to health. GHK has been recommended as a treatment for metastatic cancer, Chronic Obstructive Lung Disease, inflammation, acute lung injury, activating stem cells, pain, and anxiety. Here, we present GHK’s effects on gene expression relevant to the nervous system health and function.
The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health, L Pickart et al., Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 324832, 8 pages, doi:10.1155/2012/324832
Abstract
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions. Recently, a new mechanism of aging—detrimental epigenetic modifications—has emerged. Thus, compounds that possess antioxidant, anti-inflammatory activity as well as compounds capable of restoring copper balance and proper gene functioning may be able to prevent age- associated cognitive decline and ward off many common neurodegenerative conditions. The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins like younger tissue. It has high affinity for copper ions and easily forms a copper complex or GHK-Cu. In addition, GHK possesses a plethora of other regenerative and protective actions including antioxidant, anti-inflammatory, and wound healing properties. Recent studies revealed its ability to up- and downregulate a large number of human genes including those that are critical for neuronal development and maintenance. We propose GHK tripeptide as a possible therapeutic agent against age-associated neurodegeneration and cognitive decline.
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration, L Pickart et al., BioMed Research International Volume 2015, Article ID 648108, 7 pages http://dx.doi.org/10.1155/2015/648108
Abstract
GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan, decorin. It also restores replicative vitality to fibroblasts after radiation therapy. The molecule attracts immune and endothelial cells to the site of an injury. It accelerates wound- healing of the skin, hair follicles, gastrointestinal tract, boney tissue, and foot pads of dogs. It also induces systemic wound healing in rats, mice, and pigs. In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation. GHK has been proposed as a therapeutic agent for skin inflammation, chronic obstructive pulmonary disease, and metastatic colon cancer. It is capable of up- and downregulating at least 4,000 human genes, essentially resetting DNA to a healthier state. The present review revisits GHK’s role in skin regeneration in the light of recent discoveries.
Go directly to the source
GHK-Cu was discovered in 1973 by Prof. Loren Pickart. Since then, over 125 peer-reviewed studies are published on PubMed – The National Library of Medicine (NIH).
Reverse your age by activating your own stem cells
track your personal results by using our health tracker
determine your baseline, measure by using validated VAS (visual assessment score)
- set your goals and follow through (see cell turnover times below)
All cells are created equal but not at the same speed
some people experience instant results
personal experience may vary by the cell turnover times
Links to summaries of selected other patches (more info on request)
Glutathione (click here)
Carnosine (click here)
Aeon – anti-inflammation (click here)
Energy Enhancer – ATP (click here)
Silent Nights – melatonine (click here)
SP6 Complete – anti craving (click here)
IceWave – pain management (click here)